The Collaboration of Observational HIV Epidemiological Research Europe (COHERE) was formed in 2005 to pool and harmonize existing longitudinal data on HIV-positive persons collected across Europe to answer key research questions that, in the era of potent combination antiretroviral therapy (cART), could not be addressed adequately by individual cohorts.  COHERE uses the HIV Cohorts Data Exchange Protocol (HICDEP), a standardized and validated method of data structure and transfer, to compile data from 40 cohorts of HIV-infected people residing in Europe, representing ~300,000 HIV-positive persons, and over 2 million person-years of follow-up. Mergers of data for approved projects are conducted annually. COHERE compiles data on clinical characteristics, antiretroviral therapy and other medications, HIV seroconversion, opportunistic infections, and laboratory results (CD4-positive T-lymphocyte counts, CD8-positive lymphocytes, viral load, virological and serological tests for other infections, and HIV resistance tests) and socio demographic data.  COHERE projects have thus far focused on long-term prognosis, rare outcomes and variations across patient groups, settings and health systems.  

The Cohere Collaboration has been described in its International Journal of Epidemiology Cohort Profile

Contact Information for the Regional Coordinating Centres:

Copenhagen Bordeaux
CHIP Institut de Santé Publique,d'Epidémiologie et de Développement (ISPED)
Dorthe Raben, Director of Research Coordination
Geneviève Chêne
University of Copenhagen
CHIP, Department of Infectious
Diseases and Rheumatology
Section 2100, Finsencentret
Université de Bordeaux - INSERM U1219
146 rue Léo Saignat
F-33076 Bordeaux cedex
Blegdamsvej 9 Tel: +33 557 57 13 92
DK-2100 Copenhagen Ø Fax: +33 557 57 11 72
Tel: +45 35 45 57 82

dorthe.raben@regionh.dk Data Manager:Monique Termote
Data Manager:Casper Møller Frederiksen



Acknowledgment in UNAIDS Science now !

 The abstract of the article Mortality in migrants living with HIV in western Europe (1997-2013): a collaborative cohort study in Lancet HIV. 2015 Dec;2(12):e540-9. Epub 2015 Nov 18 was chosen to be part of the 1st issue of HIV this month (2016), made available today at  http://sciencenow.unaids.org

COHERE Presentations at CROI 2016

COHERE will be represented at CROI with the following presentations: 

1.CD4 cell response to first-line cART by HIV type in European Cohort Collaborations, presented by Linda Wittkop and Sophie Matheron for the COHERE in EuroCoord and ACHIeV2e study group 

2.Risk of Kaposi Sarcoma in HIV-positive adults on ART: a global analyses , presented by Eliane Rohner on behalf of COHERE in EuroCoord

3.Kaposi Sarcoma Risk in Children on ART from Africa, Europe and Asia, presented by Eliane Rohner and Julia Bohlius on behalf of IeDEA SA, COHERE in EuroCoord, and TREAT Asia Pediatric HIV Observational Database

4.Global Burden of Cervical Cancer in HIV-Positive Women on ART, presented by Eliane Rohner on behalf of IeDEA and COHERE in EuroCoord

5.Association of Tuberculosis with CD4 Recovery and HIV RNA Decline on ART in Europe, presented by Hansjakob Furrer on behalf of COHERE in EuroCoord

6.Safety of stopping T.gondii prophylaxis with suppressed viremia and CD4 >100, presented by Jose M Miro on behalf of COHERE in EuroCoord